Review: Why Everyone’s Talking About the SkinCeuticals A.G.E. Interrupter Ultra Serum

There are skincare launches, and then there are SkinCeuticals launches — the kind that instantly grab your attention and make you wonder if this might be the one. When I first heard about the A.G.E. Interrupter Ultra Serum, I was intrigued. A serum that promises to visibly firm, lift, and counteract the effects of glycation (a major cause of skin aging)? Sign me up.

After two months of consistent use, I can confidently say: this serum lives up to the hype.

First Impressions: Luxe from the Start

The moment I applied it, I could feel why SkinCeuticals calls this their most advanced lifting serum. The texture is silky but substantial — it glides on smoothly, absorbs beautifully, and immediately gives that “quenched” feeling. My skin drank it up without any tackiness or residue.

Even after one use, my skin felt more hydrated and supple, but what really impressed me was how it performed over time.

The Science Behind the Glow

At the heart of the A.G.E. Interrupter Ultra Serum is a powerful 34.6% concentration of Proxylane™, a patented ingredient that helps rebuild skin density and support collagen. It’s paired with Wild Fruit Flavonoids, Rhamnose, and Gentiana Lutea Root Extract — a combination that targets the glycation process (a major contributor to skin laxity and wrinkles).

In simpler terms? It helps stop the stiffening and breakdown of collagen that happens naturally with age, keeping skin firm, bouncy, and resilient.

Visible Results: Firm, Lifted, and Radiant

Around the two-week mark, I noticed that my skin was smoother and more hydrated. By four weeks, there was a real difference — my jawline felt a little tighter, my cheeks looked lifted, and my overall tone was more radiant. The serum also made my forehead lines look softer and my skin noticeably plumper.

At the eight-week point, I could actually see the lift. My lower face looked more defined, my neck felt firmer, and my skin had that “post-facial” glow every morning.

It’s rare that a serum gives both instant hydration and long-term structural results, but this one somehow does both.

Texture, Layering & Feel

One of the standout features of this formula is how beautifully it layers. In the morning, I apply it after my vitamin C serum and before moisturizer and SPF. At night, it sits perfectly over my retinol without causing irritation. It never pills, never feels heavy — just smooth, hydrated skin that stays balanced all day.

If you’re someone who enjoys that feeling of your skincare working the moment it touches your face, this will be incredibly satisfying.