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The Difference with Defenage

As we grow older, our basal skin cells age due to factors like environmental influences, sun exposure, lifestyle choices, and the natural aging process. Typical skincare targets “old” skin cells known as keratinocytes. Specifically, typical retinol stimulates “old” basal stem cells. Defenage uses a technology called Defensin to actually activate LGR6+ cells to make “new skin cells”. This is similar to your skin's natural process of wound healing, without the wound. So the difference with Defenage is it will increase the amount of new basal skin cells and create more fresh skin than any other skincare. Defensin will thicken the skin and accelerate anti-aging.

So how does defensin work? Extensive scientific and clinical studies indicate that defensins, which are natural antimicrobial peptides, play a crucial role in enabling the body to generate new skin cells by activating the master stem cells responsible for wound healing. Simply put, defensins reprogram the body and prompt these stem cells to produce fresh skin.

These master stem cells are halfway down the hair follicle and are unique in their ability to repair skin damage. Unlike many other skincare products that need to penetrate the upper layers of the skin, when defensins are applied topically, they travel down the hair follicle directly to access these master stem cells.

Defensins trigger or communicate with the master stem cells similarly to the response they would receive during microneedling, lasers, and chemical peels. Defenage coins their products as “microneedling in a bottle” because it will produce the same visible response in the skin as a micro-injury without the inflammation. DefenAge not only enhances the cosmetic outcomes of procedures but also contributes to maintaining the results over time.

We love Defenage because it can be used in conjunction with your other skincare and will enhance your routine. For example, with Defenage your retinol will have fresh cells to turn over maximizing your results. 

They come with very easy steps labeled on the product. If you are using them with your other products you will apply everything as normal and as the last step apply the Defenage 24/7 Barrier Balance Cream followed by the 8-in-1 Bioserum. If you are only using Defenage, you will cleanse and apply the 24/7 Barrier Balance followed by the 8-in-1 Bio Serum and spf. It will not cause any redness or inflammation and within 6 weeks you will see a notable improvement in fine lines, wrinkles, and pore size while your skin looks plumper and more lifted. Perfect for all skin types!

Interested in giving Defenage a try? Email us at for more info!


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